ea0081p144 | Pituitary and Neuroendocrinology | ECE2022
Maria Falch Camilla
, Arlien-Soborg Mai C.
, Dal Jakob
, Sundaram Arvind
, Michelsen Annika E.
, Ueland Thor
, Olsen Linn G.
, Heck Ansgar
, Bollerslev Jens
, Jorgensen Jens Otto
, Olarescu Cristina
Objective: Patients with acromegaly present increased insulin resistance despite reduced adipose tissue (AT) mass. Growth hormone (GH) stimulates lipolysis, but the role of AT as a metabolic factor in patients with acromegaly is still uncertain. Moreover, there is a need for better biomarkers of disease activity in acromegaly.Methods: RNA-sequencing was performed on paired subcutaneous AT (SAT) biopsies from patients (n=6) with active acromegaly...